Disease Areas
Lung cance​r

Lung cancer is one of the malignant tumors with maximal threat to population health and life, and it has fastest increase of morbidity and mortality. In recent 50 years, the report for morbidity and mortality of lung cancer increased significantly in many countries, and the morbidity and mortality of lung cancer for male are both first in all malignant tumors, and second for female. The cause of lung cancer is not yet fully understood, while mass data indicated that there is a very close relationship between smoking and lung cancer.The previous studies demonstrated: the probability for lung cancer of the long-term and mass quantity smoking person is 10~20 times than non-smoker, and smaller the initial age to start smoking, higher the probability for lung cancer. In addition, smoke is not only influencing the health of smoker directly, but also influence the health of surrounding populations, which leads to the significant incensement of the lung cancer morbidity of involuntary smoker. The morbidity for urban resident is higher than that of the villager, which may be related to the urban air pollution and cancerogenic substance in the smoke. Thus, no smoking should be advocated, and urban environmental sanitation work should be strengthened.

  • 重磅!吴一龙教授解密BLOOM研究不为人知的一面

    2018-03-07

    吴一龙教授是国内最早关注肺癌脑转移的临床专家,并在2006年就开始了脑转移的临床研究,也在AURA3的研究中特别观察了脑转移的亚组分析。这些研究成果在柳叶刀、NEJM等顶级学术期刊上发表,并在国际上引起热议。9月底CSCO大会上,【肿瘤资讯】就EGFR突变肺癌脑转移的治疗和肺癌脑转移新药AZD3759最新研究的相关问题对吴一龙教授做了专访。吴一龙教授深度讲述了AZD3759和BLOOM研究背后的故事。

  • AZD3759: 专为肺癌中枢神经系统转移而设计

    2018-03-06

    近年来,TKI药物的发展使EGFR敏感突变晚期NSCLC获得生存改善,同时耐药、CNS进展和脑膜转移的出现也成为治疗失败的主要原因。随着EGFR突变NSCLC生存期的延长,发生CNS转移和脑膜转移的病例逐渐增多,累积发生率达50%左右。目前对于发生CNS转移的治疗仍然非常有限,尤其是对脑膜转移的患者。局部放疗是脑转移重要的治疗手段,但全脑放疗(WBRT)不仅疗效有限,而且会导致神经系统认知功能损害;立体定向放疗(SRT)虽然定位准确,损伤小,但是受到病灶数量和大小的限制,不适用于所有的患者,而且目前对于如何选择WBRT和SRT尚缺少统一的标准。

  • 【2017肺癌CNS转移盘点】EGFR突变伴脑转移的NSCLC患者治疗进展

    2018-03-06

    随着肺癌诊疗水平的提高及患者生存期的延长,肺癌脑转移发生率随之升高并成为临床关注的热点问题。肺癌脑转移预后差,传统化放疗疗效有限。近年来,靶向治疗的进展,为驱动基因变异的肺癌脑转移患者带来希望。本文系统盘点了2017年EGFR突变的肺癌脑转移患者靶向治疗的重要进展。